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KMID : 0352819900060010105
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Kosin Medical Journal
1990 Volume.6 No. 1 p.105 ~ p.112
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Stein-Leventhal Syndrome associate with Endometrial Adenocarcinoma
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Abstract
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Stein-Leventhal first described a syndrome consisting of amemorrhea, infertility, and a pathologic feature of bilateral polycystic ovries. This syndrome is not infrequently associated with endometrial hyperplasia or carcinoma.
Through a number of possible theories regarding etiologic factors have been explored, the pathogenetic mechanisms are including hypothalamus-pituitary axis, adrenal factors, and ovarian steroidogenesis.
The authors present a case of Stin-Leventhal syndrome associated with endometrial adenocarcinoma in a 30-year-old female, who complained of intermittent vaginal bleeding ofr 10 years and infertility for 5 years of marriage. A diagnostic endometrial curettage showed grade I endometrial adenocarcinoma. Total hysterectomy with bilateral salpingo-oophorectomy was performed.
Both ovaries revealed symmetrical enlargement and disclosed multiple subcapsular cystic follicles. Numerous primodial follicles were noted. However, corpus luteum and albicans were not identified. The endometrial mucosal surface showed inrregular mucosal elevation which was confirmed to be endometrial adenocarcinoma.
We report this case in view of its rarity and academic interest along with a literature review on the pathogenesis.
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